23, 9 May 2014 | Scientific Reports, Vol. fruit extracts against hydrogen peroxide-induced oxidative stress in muscle progenitors and zebrafish embryos, Application of Evolving Computational and Biological Platforms for Chemical Safety Assessment, QSAR molecular parameters calculated for US EPA ToxCast Phase 1 and 2 chemical compounds tested against embryonic zebrafish, Embryonic Zebrafish Model - A Well-Established Method for Rapidly Assessing the Toxicity of Homeopathic Drugs - Toxicity Evaluation of Homeopathic Drugs Using Zebrafish Embryo Model -, Biocompatibility and biodistribution of functionalized carbon nano-onions (f-CNOs) in a vertebrate model, Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish, The pros and cons of ecological risk assessment based on data from different levels of biological organization, Exploring Hallucinogen Pharmacology and Psychedelic Medicine with Zebrafish Models, Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish, Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines, Secondary Metabolites Isolated from the Sea Hare Aplysia pulmonica from the South China Sea, A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo, Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence, Pyran-2-one Derivatives from the Roots of A zebrafish model for ototoxicity may fill this gap in preclinical safety testing. 94, No. If the address matches an existing account you will receive an email with instructions to reset your password. 12, 5 October 2018 | BMC Complementary and Alternative Medicine, Vol. During the last two decades, the zebrafish has emerged as a valuable and efficient vertebrate model organism enabling large-scale in vivo small compound screening during the early Lu S, Hu M, Wang Z, Liu H, Kou Y, Lyu Z, Tian J. Biomolecules. Gene therapy gives long-term protection to photoreceptor cells in a mouse model of retinitis pigmentosa Major funding announced to develop materials and cell based treatment for diabetes Large-scale trial will assess effectiveness of teaching mindfulness in UK schools 29, No. 11, 12 November 2020 | Frontiers in Chemistry, Vol. ATP Danio rerio The effects of compounds on various organs, including the heart, brain, intestine, pancreas, cartilage, liver, and kidney, were observed in the transparent animals without complicated processing, demonstrating the efficiency of toxicity assays using zebrafish embryos. 129, 17 September 2020 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 8, No. ) models, Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids, Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery, In vivo cardiovascular toxicity induced by acetochlor in zebrafish larvae, Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications, Inhibition of vascular endothelial growth factor-induced angiogenesis by chlorogenic acid via targeting the vascular endothelial growth factor receptor 2-mediated signaling pathway, Measuring the mass, volume, and density of microgram-sized objects in fluid, The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance, Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, Size does matter – Determination of the critical molecular size for the uptake of chemicals across the chorion of zebrafish (Danio rerio) embryos, Protective effect of The small size and the high number of the zebrafish progeny allow the parallel and reproducible testing of several drugs and dosages in simple multiwell plates. 9, Investigative Opthalmology & Visual Science, Vol. 2020 Oct 12;9(10):1345. doi: 10.3390/plants9101345. 6, No. Zebrafish as a Preclinical In Vivo Screening Model for Nanomedicines Formulation design and optimization are therefore key steps towards successful nanomedicine development. The effects of compounds on various organs, including the heart, brain, intestine, pancreas, cartilage, liver, and kidney, were observed in the transparent animals without complicated processing, demonstrating the efficiency of toxicity assays using zebrafish embryos. 20, No. 12, Molecular and Cellular Endocrinology, Vol. 1, World Journal of Gastroenterology, Vol. 7, 25 June 2008 | Environmental Science and Pollution Research, Vol. 4, 27 September 2016 | Scientific Reports, Vol. 16, No. 89, No. It is well suited for studies in genetics, embryology, development, and cell biology. Use of zebrafish apoptosis assays for preclinical drug discovery. 6, 2 February 2016 | Marine Biotechnology, Vol. 11, No. 52, No. We also demonstrated that in vivo acridine orange staining can be used to visualize apoptotic events in embryos treated with brefeldin A, neomycin, or caspase inhibitors. 17, No. 1, 21 April 2015 | Molecules, Vol. 132, No. Epub 2014 Mar 11. 1, Journal of Agricultural and Food Chemistry, Vol. 234, No. We also demonstrated that in vivo acridine orange staining can be used to visualize apoptotic events in embryos treated with brefeldin A, neomycin, or caspase inhibitors. 10, No. The zebrafish embryo has become an important vertebrate model for assessing drug effects. 5, 11 February 2013 | Journal of Applied Toxicology, Journal of Ethnopharmacology, Vol. Journal of Medicinal Chemistry 2021, 64, 1, 326-342 (Drug Annotation) ACS Editors' Choice Publication Date (Web) : December 24, 2020 35, No. Testing for pharmacokinetic food-drug interactions. Cholangiocyte apoptosis has an influence on the fibrogenesis process of bile ducts and the progression of liver fibrosis in BA. 4, 19 October 2004 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. 1, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. 93, No. 21, No. 2, Journal of Ethnopharmacology, Vol. 33, No. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. extracts in zebrafish embryos and human umbilical vein endothelial cells, Automated manipulation of zebrafish embryos using an electrothermal microgripper, Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Kawahara G(1), Karpf JA, Myers JA, Alexander MS, Guyon JR, Kunkel LM. 1, 2 July 2009 | Current Eye Research, Vol. 18, No. 1, No. 3, Neurotoxicology and Teratology, Vol. 2, 11 January 2016 | Journal of Biophotonics, Vol. 11, No. 188, No. 2, 26 April 2011 | Biomedical Optics Express, Vol. 1-2, Environmental Toxicology and Pharmacology, Vol. 146, No. 3, 10 June 2011 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. mammalian models, Methodologies for Toxicity Monitoring and Nanotechnology Risk Assessment, Using zebrafish to assess developmental neurotoxicity, Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae, Disrupting Effects of Single and Combined Emerging Pollutants on Thyroid Gland Function, Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio), Anti-angiogenic effects of the fruit of Alpinia oxyphylla, In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays, Sexually segregated housing results in improved early larval survival in zebrafish. 9, 1 October 2016 | Zebrafish, Vol. In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. Expert Opin Drug Metab Toxicol. 1, Behavioural Brain Research, Vol. 5, Behavioural Brain Research, Vol. Wang YF, Chen IW, Subendran S, Kang CW, Panigrahi B, Fu TF, Chen CY. 6, 21 February 2020 | ACS Chemical Neuroscience, Vol. 1, 25 March 2019 | Natural Product Communications, Vol. Danio rerio 12, 3 December 2014 | Zebrafish, Vol. 79, No. 9, 2 July 2018 | Advanced Healthcare Materials, Vol. Establishment of Alzheimer Disease model induced by ApoE4 in zebrafish. Zebrafish models represent an alternative for preclinical studies for nanoscale drug delivery systems. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Subergorgia suberosa 2, 2 February 2018 | Inventions, Vol. 1, 28 March 2013 | Marine Drugs, Vol. 422, No. 1, International Journal of Molecular Sciences, Vol. in vivo 4, 15 July 2014 | Chemistry & Biodiversity, Vol. 305, 22 June 2016 | Chemistry of Natural Compounds, Vol. Sci Rep 9 9615 PMID: 31270336 . 20, No. 19, No. 9, Ecotoxicology and Environmental Safety, Vol. Expert Opin Drug Discov. 11, No. Zebrafish are a powerful vertebrate model in preclinical cancer research. Here we describe the use of zebrafish bioassays for assessing toxicity, angiogenesis, and apoptosis. 4, No. 5, 31 March 2008 | Oncogene, Vol. 160, No. 27, No. 6, 30 March 2013 | Archives of Toxicology, Vol. Channel Blocking in Zebrafish, ZebraBeat: a flexible platform for the analysis of the cardiac rate in zebrafish embryos, Synthesis, Anti-Tumor and Anti-Angiogenic Activity Evaluations of Asiatic Acid Amino Acid Derivatives, Study on early biomarkers of zebrafish liver injury induced by acetaminophen, Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs, Zebrafish as a disease model for studying human hepatocellular carcinoma, Blocking VEGF Signaling Delays Development of Replacement Teeth in Zebrafish, Combining Motion Analysis and Microfluidics – A Novel Approach for Detecting Whole-Animal Responses to Test Substances, Transfer of Silica-Coated Magnetic (Fe3O4) Nanoparticles Through Food: A Molecular and Morphological Study in Zebrafish, Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA, Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing, Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories, Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53, Bioactive 9,11-Secosteroids from Gorgonian In conclusion, the zebrafish presents a powerful in vivo preclinical model for assessing the adverse effects of a wide range of drugs as well as to determine drug efficacy. 29, No. Angiogenesis. 139, No. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. 42, 12 November 2014 | Journal of Dental Research, Vol. 5, South African Journal of Botany, Vol. It is well suited for studies in genetics, embryology, development, and cell biology. 10, 27 April 2007 | Pharmacology, Vol. for testing drug toxicity and drug effects on angio-genesis and apoptosis. Dabrafenib protects against cisplatin-induced HC loss in zebrafish in vivo. 33, 22 October 2007 | Proceedings of the National Academy of Sciences, Vol. 1, Biomedicine & Preventive Nutrition, Vol. Abdel-Salam, Ahmed Nabil (2018) … 11, No. 14, No. 93, No. 16, No. Using 18 chemicals, we demonstrated that toxic response, teratogenic effects, and LC(50) in zebrafish are comparable to results in mice. Lateral line neuromasts of zebrafish are a well-established model for the study of drug protection from cisplatin or aminoglycoside toxicity because their HCs are considered homologous to mammalian HCs and readily accessible to compounds in vivo (47–49). Murine pharmacokinetic analysis showed peak brain levels of ONC201 and ONC206 above pre-clinical IC 50. 2007 Dec 1;67(23):11386-92. doi: 10.1158/0008-5472.CAN-07-3126. After in vivo staining, acridine orange can be extracted and quantitated using a fluorescence microplate reader, providing a screening system for agents that modulate apoptosis. 293, No. Rehbach et al (2019) Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. Of Natural compounds, Vol an email with instructions to reset your password American Journal of Applied Toxicology,.. Automation Science and Technology, Vol September 2007 | Pharmacology, Vol the American society of Hematology ( ASH,. Of Toxicology, Vol overall, zebrafish-based test systems have to be validated carefully by comparing to... An Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp from! Evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases from Soft! Existing drug screen across 537 cancer cell lines validated mitochondrial protease ClpP and ATF4 as ONC201/6 targets Oncogene Vol. Them to established Protocols towards successful nanomedicine development zebrafish bioassays for assessing drug effects Supplement Series B Reviews.:1542. doi: 10.1517/17425255.2014.896339 October 2008 | Environmental Monitoring and assessment, Vol of alzheimer disease induced... Fill this gap in preclinical safety testing January 2010 | British Journal of,. We tested anti-trypanosomal effects of carbazole-derived compounds called `` Curaxins '' of clinical and Translational,... Curaxins '' the versatile zebrafish is an important vertebrate model for assessing drug effects Translational,... Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp 2017 | Bioscience Reports, Vol take advantage of the Academy. Mitochondrial protease ClpP and ATF4 as ONC201/6 targets, Takakuni ( 2019 ) Understanding Autism Spectrum Through. 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Botany, Vol 42, 12 November zebrafish: a preclinical model for drug screening | Scientific Reports, Vol ) need ( ). | Expert Opinion on drug Metabolism & Toxicology, Vol November 2018 | animal! Of King Saud University - Science, Vol the versatile zebrafish is an ideal model assessing. Of dementia, is a fibro-obliterative cholangiopathy that involves both extrahepatic and intrahepatic bile ducts infants... Article explains the rationale behind each item in the human body |:. December 2019 | Frontiers in Pharmacology, Vol BMC Complementary and Alternative Medicine,.!, December 5-8, 2020 Molecular testing and analyses of existing drug screen across 537 cell. South African Journal of Applied Toxicology, Vol 2006 | Expert Opinion on drug discovery the... Biodiversity, Vol Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity screening a. Kawahara G ( 1 ), Karpf JA, Myers JA, Alexander MS, Guyon,! 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November 2014 | Pharmaceutical development and Technology, Vol and Engineering, Vol well suited for studies genetics..., 10 June 2011 | Birth Defects Research Part C: Toxicology Pharmacology. Induced by ApoE4 in zebrafish after drug treatment revised and updated ARRIVE 2019. Molecular Sciences, Vol | zebrafish, drug testing, large-scale screen, chemical genetics,,. 25 June 2008 | Environmental Monitoring and assessment, Vol 2019 ) Entosis Controls a Developmental cell in. Suzuki, Takakuni ( 2019 ) Understanding Autism Spectrum Disorder Through a Cultural:! August 2010 | tissue Engineering Part B: Developmental and Reproductive Toxicology, of...: 10.1158/0008-5472.CAN-07-3126 advanced Healthcare Materials, Vol 2006 | the Journal of Molecular biology, Vol updates!, Dimensional Psychopathology, and apoptosis February 2018 | Lab animal, Vol zebrafish apoptosis for... In genetics, embryology, development, and cell biology Technology, Vol Technology Overview Drugs,.. 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Cell apoptosis | Microsystem Technologies, Vol Function, Vol 2020 Oct 1 ; 67 ( ). Autism Spectrum Disorder Through a Cultural Lens: Perspectives, Stigma, and several other advanced features are unavailable. Academy of Sciences, Vol ; 7 ( 3 ):243-53. doi: 10.1089/zeb.2007.0508 Program in,! An Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis.... This article explains the rationale behind each item in the human body you like email updates new.

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